解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章
doi:10.1016/0143-4179(85)90010-1
更新日期:1985-07-01 00:00:00
abstract::Immunoreactive substance P (SPI) and somatostatin (SOMI) are found in spinal cord but their physiological roles remain speculative. Several classes of neuropeptides, including endogenous opioids and thyrotropin-releasing hormone (TRH), have been implicated in the pathogenesis or recovery from spinal cord injury. In th...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90092-7
更新日期:1985-06-01 00:00:00
abstract::Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90095-2
更新日期:1985-06-01 00:00:00
abstract::Acid extracts from mouse Neuroblastoma x rat Glioma hybrid cells have been purified by means of Sep-Pak C-18 and fractionated by high performance liquid chromatography. Each fraction has been submitted to a sensitive beta-endorphin radioimmunoassay and an immunoreactivity peak at camel beta-endorphin retention time wa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90130-1
更新日期:1985-03-01 00:00:00
abstract::The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90047-2
更新日期:1985-02-01 00:00:00
abstract::Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90044-7
更新日期:1985-02-01 00:00:00
abstract::[3H]-Dynorphin A (1-8) was degraded in brain homogenates at 25 degrees and even at 0 degree C. The peptidase inhibitors bestatin and captopril almost completely protected[3H]-dynorphin A (1-8) from degradation at 0 degree C but had only little effect on binding at this temperature. At 25 degrees C, the binding of [3H]...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90072-1
更新日期:1985-02-01 00:00:00
abstract::Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90019-8
更新日期:1985-02-01 00:00:00
abstract::In this study guinea pig, rat and bovine striatal extracts have been shown to contain putative opioid peptide precursors in the molecular weight (Mr) range 2000-greater than 70000. The material eluting greater than 70 kDalton contained bioassayable opioid activity but not Met- or Leu-enkephalin-like immunoreactivities...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90069-1
更新日期:1985-02-01 00:00:00
abstract::In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90044-1
更新日期:1984-12-01 00:00:00
abstract::In binding assays with homogenates of the myenteric plexus-longitudinal muscle of the guinea-pig, beta-funaltrexamine is more potent at displacing mu-binding than kappa-binding. Incubation of homogenates with beta-funaltrexamine (100 or 1000 nM) for 30 min at 37 degrees C followed by repeated washing with drug-free Tr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90054-4
更新日期:1984-12-01 00:00:00
abstract::DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for delta opioid receptors. Intracerebroventricular (i.c.v.) administration of each analog acutely produces a complex EEG response in rats characterized by a d...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90065-9
更新日期:1984-12-01 00:00:00
abstract::After chronic treatment with morphine, the muscular rigidity mediated by opioid receptors in the striatum, was gradually replaced by stereotypic behaviour indicating an increased nigrostriatal dopaminergic activity. These results suggest that one behavioural pattern, originating in the striatum, was replaced by anothe...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90018-0
更新日期:1984-12-01 00:00:00
abstract::Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90033-7
更新日期:1984-12-01 00:00:00
abstract::D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90001-5
更新日期:1984-06-01 00:00:00
abstract::Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90105-7
更新日期:1984-05-01 00:00:00
abstract::The effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH, a hypothalamic heptapeptide with weak CRF activity were investigated on the in vitro uptake and release of radiolabelled dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in rat brain hypothalamic slices. In a doses of 5 X 10(-6) M and 10(-5) M the heptapeptide sig...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90106-9
更新日期:1984-05-01 00:00:00
abstract::The effects of graded amounts of centrally injected [intracerebroventricular, i.c.v.] oxytocin [OXT] have been studied on the steady-state level and pargyline-induced accumulation of serotonin [5-HT] in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90125-2
更新日期:1984-03-01 00:00:00
abstract::To find out, whether microheterogeneity of neurophysins is due to aging of neurosecretory granules we investigated neurophysin proteins of porcine origin from newly formed and aged granules, as well as from two different extraction methods from whole posterior pituitary glands by high performance liquid chromatography...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90003-3
更新日期:1983-12-01 00:00:00
abstract::Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90012-4
更新日期:1983-12-01 00:00:00
abstract::Highly purified porcine neurophysin-II, prepared from pig posterior pituitary lobe tissue was injected into fifteen rabbits in the preparation of anti-neurophysin sera. All antisera, when used in association with immunohistochemical procedures, gave an immunoreaction in structures of the rat hypothalamo-neurohypophysi...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90038-0
更新日期:1983-10-01 00:00:00
abstract::We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90047-1
更新日期:1983-04-01 00:00:00
abstract::Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90010-5
更新日期:1982-12-01 00:00:00
abstract::The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90066-x
更新日期:1982-10-01 00:00:00
abstract::Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90061-0
更新日期:1982-10-01 00:00:00